Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 4/20 | 0.33 |
| ▸ | CES1 | P23141 | 4/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6918534 | 1.00 | BMP1 (0.34) | BMP1MMP2RENSMN1; SMN2ALDH1A1 | |
| SCHEMBL7250425 | 0.93 | MMP1 (0.34) | BMP1MMP2RENSMN1; SMN2ALDH1A1 | |
| SCHEMBL6918536 | 0.87 | BMP1 (0.40) | BMP1RENALDH1A1KDM4ETHRB | |
| SCHEMBL6801144 | 0.85 | CTSL (0.33) | MMP2RENALDH1A1CTSKCTSL | |
| SCHEMBL6806939 | 0.82 | CTSL (0.36) | MMP2CTSKCTSLCTSBCTSS | |
| SCHEMBL6807154 | 0.80 | KMT2A (0.36) | MMP2RENALDH1A1CTSLCTSB | |
| SCHEMBL6801151 | 0.79 | CTSL (0.39) | MMP2RENCTSKCTSLCTSB | |
| SCHEMBL6799439 | 0.78 | MAPT (0.39) | MMP2ALDH1A1CTSKCTSLCTSB | |
| SCHEMBL6806942 | 0.75 | CTSL (0.43) | MMP2RENCTSKCTSLCTSB | |
| SCHEMBL6807131 | 0.71 | PPARG (0.38) | MMP2SMN1; SMN2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730671-B2 | ENZYME INHIBITOR TREATING AUTOIMMUNE DISEASES, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-05-04 | — | — | US | disclosed |