Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18041383 | 0.77 | FTO (0.42) | NPC1RAB9APOLBLMNASMN1; SMN2 | |
| SCHEMBL22581561 | 0.77 | ADORA2A (0.47) | NPC1RAB9AL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL19555318 | 0.77 | ESR1 (0.41) | NPC1RAB9APOLBL3MBTL1LMNA | |
| SCHEMBL8358807 | 0.77 | NAPRT (0.42) | NPC1RAB9AL3MBTL1SMN1; SMN2NAPRT | |
| SCHEMBL2099046 | 0.76 | KDM4E (0.47) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL15173772 | 0.76 | ADORA2A (0.44) | NPC1RAB9APOLBSMN1; SMN2KMT2A | |
| SCHEMBL4121736 | 0.75 | NAPRT (0.41) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2772493 | 0.75 | NAPRT (0.41) | NPC1RAB9AL3MBTL1SMN1; SMN2NAPRT | |
| SCHEMBL26093875 | 0.75 | ALDH1A1 (0.39) | NPC1RAB9APOLBL3MBTL1LMNA | |
| SCHEMBL29546318 | 0.74 | SIRT6 (0.44) | NPC1RAB9APOLBL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421872-A1 | THIA-TRIAZA-AS-INDACENES AS PI3-KINASES INHIBITORS FOR THE TREATMENT OF CANCER | Boehringer Ingelheim International GmbH (DE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122091-A1 | THIA-TRIAZA-AS-INDACENES AS PI3-KINASES INHIBITORS FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-28 | — | — | WO | disclosed |