SCHEMBL691866

SCHEMBL691866

C=CC(=O)OCCC[SiH](Cl)Cl

nearest known ligand 0.63

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.63
ALDH1A1 P00352 4/20 0.63
CYP3A4 P08684 2/20 0.63
HPGD P15428 1/20 0.57
TP53 P04637 3/20 0.52
HIF1A Q16665 3/20 0.52
HSD17B10 Q99714 1/20 0.52
THRB P10828 2/20 0.40
MAPK1 P28482 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ATM Q13315 1/20 0.36
HCAR2 Q8TDS4 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL840780 0.94 TSHR (0.67) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL30418050 0.92 TSHR (0.70) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL30417430 0.92 TSHR (0.70) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL9805399 0.92 TSHR (0.70) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL16253926 0.88 TSHR (0.56) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL21694054 0.82 TSHR (0.65) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL31125980 0.80 TSHR (0.53) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL244114 0.80 TSHR (0.95) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL321925 0.80 TSHR (0.85) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL1585542 0.80 TSHR (0.63) TSHRALDH1A1CYP3A4HPGDTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110265608-A A kind of high pressure resistant lithium ion battery nano coating diaphragm and preparation method thereof 新乡市中科科技有限公司 2019-09-20 CN claimed
US-9823520-B2 Liquid crystal display apparatus and method for manufacturing the same SAMSUNG DISPLAY CO., LTD. (KR) 2017-11-21 US claimed
CN-106475045-A For removing modified bentonite adsorbent of copper and preparation method thereof in polluted-water 北京源清益壤环保科技有限公司 2017-03-08 CN claimed
US-20150168763-A1 LIQUID CRYSTAL DISPLAY APPARATUS AND METHOD FOR MANUFACTURING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2015-06-18 US claimed
EP-2599847-A1 A Silicone Acrylate Hybrid Composition and Method of Making Same Dow Corning Corporation (US) 2013-06-05 EP claimed
EP-2024406-B1 A SILICONE ACRYLATE HYBRID COMPOSITION DOW CORNING (US) 2012-08-01 EP claimed
US-20120114737-A1 SILICONE ACRYLATE HYBRID COMPOSITION AND METHOD OF MAKING SAME DOW SILICONES CORPORATION 2012-05-10 US claimed
US-20090196911-A1 Silicone Acrylate Hybride Composition and Method Of Making Same DOW SILICONES CORPORATION 2009-08-06 US claimed
EP-2024406-A2 A SILICONE ACRYLATE HYBRID COMPOSITION DOW CORNING CORPORATION (US) 2009-02-18 EP claimed
EP-1940368-A2 TRANSDERMAL DRUG DELIVERY SYSTEM WITH ACRYLATE OR METHACRYLATE FUNCTIONAL PRESSURE SENSITIVE ADHESIVE COMPOSITION DOW CORNING CORPORATION (US) 2008-07-09 EP claimed
WO-2007145996-A9 A SILICONE ACRYLATE HYBRID COMPOSITION DOW CORNING (US) 2008-02-14 WO claimed
WO-2007145996-A2 A SILICONE ACRYLATE HYBRID COMPOSITION DOW CORNING CORPORATION (US) 2007-12-21 WO claimed
WO-2007050580-A2 TRANSDERMAL DRUG DELIVERY SYSTEM WITH ACRYLATE OR METHACRYLATE FUNCTIONAL PRESSURE SENSITIVE ADHESIVE COMPOSITION DOW CORNING CORPORATION (US) 2007-05-03 WO claimed
EP-4395749-B1 TRANSDERMAL THERAPEUTIC SYSTEM FOR THE TRANSDERMAL ADMINISTRATION OF GUANFACINE COMPRISING GUANFACINE AND A MONO-CARBOXYLIC ACID LTS LOHMANN THERAPIE SYSTEME AG (DE) 2025-11-19 EP disclosed
EP-3996692-B1 TRANSDERMAL THERAPEUTIC SYSTEM COMPRISING AN ACTIVE AGENT-CONTAINING LAYER COMPRISING A SILICONE-CONTAINING POLYMER AND A SKIN CONTACT LAYER COMPRISING A SILICONE GEL ADHESIVE LTS LOHMANN THERAPIE SYSTEME AG (DE) 2025-06-11 EP disclosed
US-12214088-B2 Transdermal therapeutic system for the transdermal administration of guanfacine comprising at least one additive LTS LOHMANN THERAPIE-SYSTEME AG (DE) 2025-02-04 US disclosed
WO-2007145996-A2 A SILICONE ACRYLATE HYBRID COMPOSITION DOW CORNING CORPORATION (US) 2007-12-21 WO disclosed
WO-2007050580-A2 TRANSDERMAL DRUG DELIVERY SYSTEM WITH ACRYLATE OR METHACRYLATE FUNCTIONAL PRESSURE SENSITIVE ADHESIVE COMPOSITION DOW CORNING CORPORATION (US) 2007-05-03 WO disclosed
JP-2000159782-A CYCLOTETRASILOXANE HAVING (METH)ACRYLOXYPROPYL GROUP, AND PRODUCTION THEREOF SHIN ETSU CHEM CO LTD 2000-06-13 JP disclosed
US-5051486-A Comb like polymers containing siloxane groups with polyoxyalkylene groups NIPPON OIL CO., LTD. (JP) 1991-09-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12214088-B2 Transdermal therapeutic system for the transdermal administration of guanfacine comprising at least one additive GUCY1A2, PDE2A, PDE3A TSHR 2021/4885ALDH1A1 2210/4885CYP3A4 2199/4885
US-20120114737-A1 SILICONE ACRYLATE HYBRID COMPOSITION AND METHOD OF MAKING SAME MMS19, CAD, ACR TSHR 4740/4885ALDH1A1 2598/4885CYP3A4 4282/4885
US-20090196911-A1 Silicone Acrylate Hybride Composition and Method Of Making Same MMS19, CAD, ACR TSHR 4760/4885ALDH1A1 2679/4885CYP3A4 4382/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.