Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | STAT3 | P40763 | 2/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | TSPO | P30536 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2315428 | 0.90 | PKM (0.38) | PKMDGAT1SLC6A2SLC6A3OPRM1 | |
| SCHEMBL6917782 | 0.80 | SIGMAR1 (0.45) | DGAT1SLC6A2SIGMAR1 | |
| SCHEMBL2315414 | 0.80 | MDM2 (0.37) | DGAT1 | |
| SCHEMBL2318519 | 0.80 | SIGMAR1 (0.37) | PKMSLC6A2SIGMAR1MAOA | |
| SCHEMBL6918642 | 0.80 | MAOA (0.39) | SLC6A2KDM1AMAOAMAOB | |
| SCHEMBL10032827 | 0.76 | GPR88 (0.42) | KDM1ASIGMAR1MAOAMAOB | |
| SCHEMBL2316326 | 0.76 | PSEN1 (0.42) | SLC6A2MAOA | |
| SCHEMBL6916644 | 0.74 | MDM2 (0.40) | OPRM1KDM1AMAOAMAOB | |
| SCHEMBL2315082 | 0.74 | SLC6A2 (0.38) | PKMDGAT1SLC6A2SLC6A3MAOA | |
| SCHEMBL2317127 | 0.74 | PSEN1 (0.41) | DGAT1SIGMAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011092611-A1 | AMINOCYCLOHEXANES AND AMINOTETRAHYDROPYRANS AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2011-08-04 | — | — | WO | disclosed |