Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.50 |
| ▸ | OPRD1 known ✓ | P41143 | 2/20 | 0.50 |
| ▸ | OPRK1 known ✓ | P41145 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 6/20 | 0.49 |
| ▸ | CA1 | P00915 | 6/20 | 0.49 |
| ▸ | CA2 | P00918 | 6/20 | 0.49 |
| ▸ | CA4 | P22748 | 3/20 | 0.49 |
| ▸ | THRA | P10827 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL11590482 | 0.92 | KCNH2 (0.68) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| Trolamine SCHEMBL671041 | 0.92 | KCNH2 (0.68) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| Trolamine SCHEMBL28434418 | 0.91 | KCNH2 (0.66) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| Sulfuric Acid SCHEMBL491381 | 0.87 | MEN1 (0.59) | KCNH2CA2SIGMAR1MEN1KMT2A | |
| Sulfuric Acid SCHEMBL11677161 | 0.87 | MEN1 (0.59) | KCNH2CA2SIGMAR1MEN1KMT2A | |
| Sulfuric Acid SCHEMBL18298131 | 0.87 | MEN1 (0.59) | KCNH2CA2SIGMAR1MEN1KMT2A | |
| Sulfuric Acid SCHEMBL38021 | 0.87 | MEN1 (0.59) | KCNH2CA2SIGMAR1MEN1KMT2A | |
| Sulfuric Acid SCHEMBL18298127 | 0.87 | MEN1 (0.59) | KCNH2CA2SIGMAR1MEN1KMT2A | |
| Sulfuric Acid SCHEMBL10624570 | 0.87 | MEN1 (0.59) | KCNH2CA2SIGMAR1MEN1KMT2A | |
| Sulfuric Acid SCHEMBL6157374 | 0.87 | MEN1 (0.59) | KCNH2CA2SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023675-B2 | Polymer nanoparticles | ETH ZUERICH (CH) | 2018-07-17 | — | — | US | disclosed |
| EP-2630163-B1 | ULTRA FAST PROCESS FOR THE PREPARATION OF POLYMER NANOPARTICLES | MAX PLANCK GESELLSCHAFT (DE) | 2018-05-16 | — | — | EP | disclosed |
| EP-3199232-A1 | HOLLOW METAL NANOPARTICLE, CATALYST INCLUDING SAME, AND METHOD FOR MANUFACTURING HOLLOW METAL NANOPARTICLE | LG Chem, Ltd. (KR) | 2017-08-02 | — | — | EP | disclosed |
| US-20170128915-A1 | HOLLOW METAL NANOPARTICLE, CATALYST INCLUDING SAME, AND METHOD FOR MANUFACTURING HOLLOW METAL NANOPARTICLE | LG CHEM, LTD. (KR) | 2017-05-11 | — | — | US | disclosed |
| US-9345651-B2 | Oil-in-water emulsion composition and method for producing the same | CHANEL PARFUMS BEAUTE (FR) | 2016-05-24 | — | — | US | disclosed |
| US-20160024241-A1 | POLYMER NANOPARTICLES | ETH ZUERICH (CH) | 2016-01-28 | — | — | US | disclosed |
| US-9181358-B2 | Polymer nanoparticles | ETH ZUERICH (CH) | 2015-11-10 | — | — | US | disclosed |
| US-8921444-B2 | Process for the modification of polymers, in particular polymer nanoparticles | MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2014-12-30 | — | — | US | disclosed |
| US-8921442-B2 | Ultra fast process for the preparation of polymer nanoparticles | MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E. V. (DE) | 2014-12-30 | — | — | US | disclosed |
| EP-2421903-B1 | POLYMER NANOPARTICLES | ETH ZUERICH (CH) | 2014-11-19 | — | — | EP | disclosed |
| EP-2630163-A1 | ULTRA FAST PROCESS FOR THE PREPARATION OF POLYMER NANOPARTICLES | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2013-08-28 | — | — | EP | disclosed |
| EP-2630164-A1 | PROCESS FOR THE MODIFICATION OF POLYMERS, IN PARTICULAR POLYMER NANOPARTICLES | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2013-08-28 | — | — | EP | disclosed |
| US-20120115963-A1 | POLYMER NANOPARTICLES | ETH ZUERICH (CH) | 2012-05-10 | — | — | US | disclosed |
| WO-2012052148-A1 | ULTRA FAST PROCESS FOR THE PREPARATION OF POLYMER NANOPARTICLES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012052147-A1 | PROCESS FOR THE MODIFICATION OF POLYMERS, IN PARTICULAR POLYMER NANOPARTICLES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2012-04-26 | — | — | WO | disclosed |
| EP-2421903-A1 | POLYMER NANOPARTICLES | ETH Zurich (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121387-A1 | POLYMER NANOPARTICLES | ETH Zürich (CH) | 2010-10-28 | — | — | WO | disclosed |
| EP-1466582-B1 | Hair treatment agent comprising a silylated peptide-silane copolymer | SEIWA KASEI CO LTD (JP) | 2009-07-29 | — | — | EP | disclosed |
| US-20040202637-A1 | Hair treatment agent, shampoo and hair coloring agent | SEIWA KASEI COMPANY, LIMITED (JP) | 2004-10-14 | — | — | US | disclosed |
| EP-1466582-A1 | Hair treatment composition comprising a silylated peptide-silane copolymer | Seiwa Kasei Company, Limited (JP) | 2004-10-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024241-A1 | POLYMER NANOPARTICLES | POLQ, POLN, POLA1 | OPRM1 1759/4885OPRD1 1802/4885OPRK1 1516/4885 |
| US-20040202637-A1 | Hair treatment agent, shampoo and hair coloring agent | SRM, SRMS, SPOP | OPRM1 932/4885OPRD1 1483/4885OPRK1 2325/4885 |
| US-10023675-B2 | Polymer nanoparticles | POLQ, POLN, POLA1 | OPRM1 1759/4885OPRD1 1802/4885OPRK1 1516/4885 |
| US-20120115963-A1 | POLYMER NANOPARTICLES | POLQ, POLN, POLA1 | OPRM1 1759/4885OPRD1 1802/4885OPRK1 1516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.