Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 9/20 | 0.45 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826032 | 0.79 | P2RY12 (0.49) | P2RY12CXCR3GRM5 | |
| SCHEMBL6916055 | 0.78 | HSD11B1 (0.45) | P2RY12CXCR3GRM5HSD17B10 | |
| SCHEMBL13648884 | 0.75 | CXCR3 (0.55) | CXCR3LRRK2 | |
| Hydrochloric Acid SCHEMBL3976856 | 0.74 | CXCR3 (0.54) | CXCR3LRRK2 | |
| SCHEMBL6919706 | 0.73 | CYP2C9 (0.45) | P2RY12CXCR3GRM5KDM4EMEN1 | |
| SCHEMBL6826225 | 0.73 | HPGD (0.49) | CXCR3MEN1KMT2A | |
| SCHEMBL6820189 | 0.72 | CXCR3 (0.44) | P2RY12CXCR3GRM5KDM4E | |
| SCHEMBL6917988 | 0.72 | CCR4 (0.44) | P2RY12CXCR3GRM5 | |
| SCHEMBL6823744 | 0.72 | KMT2A (0.48) | P2RY12CXCR3GRM5HSD17B10KDM4E | |
| SCHEMBL6820208 | 0.72 | CXCR3 (0.43) | P2RY12CXCR3GRM5KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074287-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-09-02 | — | — | WO | claimed |
| WO-2004074287-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-09-02 | — | — | WO | disclosed |