SCHEMBL6919706

SCHEMBL6919706

O=C(c1cnc(N2CCC(Oc3ncccn3)CC2)c(Cl)c1)N1CCCC1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 4/20 0.45
CYP2C19 P33261 4/20 0.45
CXCR3 P49682 3/20 0.45
MAPT P10636 2/20 0.45
GAA P10253 1/20 0.45
EPHX2 P34913 1/20 0.44
CYP2J2 P51589 1/20 0.44
ALDH1A1 P00352 3/20 0.43
KDM4E B2RXH2 2/20 0.43
HPGD P15428 2/20 0.43
HTT P42858 1/20 0.43
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
MALT1 Q9UDY8 2/20 0.42
GRM5 P41594 1/20 0.41
P2RY12 Q9H244 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6821246 0.87 CYP2C9 (0.46) CYP2C9CYP2C19CXCR3MAPTGAA
SCHEMBL6821180 0.81 CXCR3 (0.42) CYP2C9CYP2C19CXCR3MAPTGAA
SCHEMBL7190383 0.81 CXCR3 (0.42) CYP2C9CYP2C19CXCR3MAPTGAA
SCHEMBL6825456 0.79 CXCR3 (0.43) CYP2C9CYP2C19CXCR3MAPTGAA
SCHEMBL13648884 0.77 CXCR3 (0.55) CXCR3
SCHEMBL7195135 0.76 CXCR3 (0.45) CXCR3GRM5
SCHEMBL6826032 0.76 P2RY12 (0.49) CXCR3HPGDGRM5P2RY12
Hydrochloric Acid SCHEMBL3976856 0.76 CXCR3 (0.54) CXCR3
SCHEMBL6823744 0.75 KMT2A (0.48) CXCR3ALDH1A1KDM4EHPGDHTT
SCHEMBL6919652 0.73 P2RY12 (0.45) CXCR3KDM4EHTTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004074278-A1 NOVEL COMPOUNDS ASTRAZENECA AB (SE) 2004-09-02 WO disclosed