Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | NEK2 | P51955 | 1/20 | 0.49 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920030 | 0.91 | DYRK1A (0.53) | HSD17B1HSD17B2CHEK1FGFR1NEK2 | |
| SCHEMBL6915290 | 0.80 | JAK2 (0.41) | CHEK1FGFR1DYRK1ADYRK1B | |
| SCHEMBL12907599 | 0.69 | CHEK1 (0.59) | HSD17B1HSD17B2CHEK1FGFR1NEK2 | |
| SCHEMBL12907242 | 0.69 | MAP4K4 (0.61) | CHEK1FGFR1NEK2MAPK15DYRK1A | |
| SCHEMBL8577619 | 0.68 | SMN1; SMN2 (0.70) | HSD17B1HSD17B2NPC1RAB9ACYP17A1 | |
| SCHEMBL28664306 | 0.67 | FYN (0.56) | CHEK1FGFR1NEK2MAPK15DYRK1A | |
| SCHEMBL30896407 | 0.67 | GPR3 (0.45) | CHEK1FGFR1DYRK1ADYRK1BMAP4K4 | |
| SCHEMBL12821681 | 0.67 | CHEK1 (0.69) | CHEK1FGFR1NEK2MAPK15DYRK1A | |
| SCHEMBL29930674 | 0.67 | DYRK1A (0.71) | HSD17B1HSD17B2CHEK1FGFR1NEK2 | |
| SCHEMBL3786463 | 0.67 | NQO2 (0.73) | HSD17B1HSD17B2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |