Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 6/20 | 0.47 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | DRD1 | P21728 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD5 | P21918 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | GUSB | P08236 | 2/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17351087 | 0.98 | GNAO1 (0.50) | GNAO1GNAI3GNAI1BCHEHTR1A | |
| SCHEMBL30379435 | 0.95 | GNAI3 (0.41) | GNAO1GNAI3GNAI1HTR1ADRD1 | |
| SCHEMBL9869321 | 0.95 | GNAI3 (0.41) | GNAO1GNAI3GNAI1HTR1ADRD1 | |
| SCHEMBL29532370 | 0.89 | GNAO1 (0.55) | GNAO1GNAI3GNAI1GUSBEBP | |
| SCHEMBL29531997 | 0.87 | GNAO1 (0.58) | GNAO1GNAI3GNAI1GUSBEBP | |
| SCHEMBL9871152 | 0.87 | L3MBTL3 (0.42) | DRD1DRD4DRD5DRD3DRD2 | |
| SCHEMBL27282631 | 0.87 | L3MBTL3 (0.42) | DRD1DRD4DRD5DRD3DRD2 | |
| SCHEMBL27282016 | 0.87 | L3MBTL3 (0.42) | DRD1DRD4DRD5DRD3DRD2 | |
| SCHEMBL16625964 | 0.84 | BCHE (0.44) | BCHEDRD3DRD2 | |
| SCHEMBL19711120 | 0.83 | GUSB (0.53) | GNAO1GNAI3GNAI1BCHEGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009543-A2 | 1-CARBONYL-4-CYANO-PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS HEPATITIS C VIRUS INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-01-29 | — | — | WO | disclosed |