Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 3/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | GLB1 | P16278 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30379435 | 1.00 | GNAI3 (0.41) | GNAI3GNAO1GNAI1HTR1ADRD2 | |
| SCHEMBL6920677 | 0.95 | GNAO1 (0.47) | GNAI3GNAO1GNAI1HTR1ADRD2 | |
| SCHEMBL17351087 | 0.93 | GNAO1 (0.50) | GNAI3GNAO1GNAI1HTR1ADRD2 | |
| SCHEMBL16625964 | 0.89 | BCHE (0.44) | DRD2DRD3 | |
| SCHEMBL27756873 | 0.89 | GNAO1 (0.47) | GNAI3GNAO1GNAI1DRD2DRD3 | |
| SCHEMBL27282631 | 0.89 | L3MBTL3 (0.42) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL27282016 | 0.89 | L3MBTL3 (0.42) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL9871152 | 0.89 | L3MBTL3 (0.42) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL10511195 | 0.88 | BCHE (0.40) | L3MBTL3 | |
| SCHEMBL29532370 | 0.83 | GNAO1 (0.55) | GNAI3GNAO1GNAI1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419527-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2024-08-28 | — | — | EP | disclosed |
| WO-2023067355-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2023-04-27 | — | — | WO | disclosed |
| US-5063228-A | 4-(substitutedaminoethyl)-3,4-dihydro-2-alkylpyrimido[1,6-a]benzimidazol-1(2H)-ones as antiarrhythmic agents | A. H. ROBBINS COMPANY, INCORPORATED (US) | 1991-11-05 | — | — | US | disclosed |