Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.33 |
| ▸ | SPR | P35270 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125247 | 0.83 | KDM4E (0.42) | KDM4EKMT2ALMNANPC1RAB9A | |
| SCHEMBL10751737 | 0.81 | LMNA (0.43) | KDM4EALDH1A1MEN1KMT2ARXFP1 | |
| SCHEMBL6919650 | 0.77 | KMT2A (0.46) | KDM4EALDH1A1KMT2ALMNASPR | |
| SCHEMBL6915552 | 0.77 | SPR (0.33) | KDM4EALDH1A1KMT2ARXFP1SPR | |
| SCHEMBL27588870 | 0.75 | KDM4E (0.46) | KDM4EALDH1A1LMNAACVR1SPR | |
| SCHEMBL10751104 | 0.71 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL10751196 | 0.71 | ALDH1A1 (0.50) | ALDH1A1LMNASPRPOLBNPC1 | |
| SCHEMBL10755186 | 0.71 | MAPT (0.49) | ALDH1A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL10755526 | 0.69 | MAPT (0.46) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL10754025 | 0.69 | KDM4E (0.43) | KDM4EALDH1A1MEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |