SCHEMBL6921065

SCHEMBL6921065

FC(F)(F)c1cccc(C2CCN(CCc3cccc4ccccc34)CC2)c1

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 0.63
DRD4 P21917 1/20 0.53
GRM2 Q14416 1/20 0.53
CHRM4 P08173 1/20 0.46
HTR2C P28335 2/20 0.46
HTR1A P08908 1/20 0.46
SLC6A4 P31645 1/20 0.46
KDM4A O75164 1/20 0.45
KDM4B O94953 1/20 0.45
KDM5C P41229 1/20 0.45
KDM5B Q9UGL1 1/20 0.45
CHRNA7 P36544 1/20 0.44
IDE P14735 1/20 0.44
UBE2N P61088 1/20 0.44
SIGMAR1 Q99720 1/20 0.43
CCR5 P51681 1/20 0.43
ESR1 P03372 1/20 0.43
ESR2 Q92731 1/20 0.43
MC4R P32245 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10475673 0.85 DRD2 (0.65) DRD2DRD4GRM2CHRM4HTR2C
SCHEMBL9422688 0.82 DRD2 (0.63) DRD2DRD4GRM2CHRM4HTR2C
Hydrochloric Acid SCHEMBL9305904 0.81 DRD2 (0.62) DRD2DRD4GRM2CHRM4HTR2C
SCHEMBL6921067 0.78 IDE (0.41) DRD2DRD4GRM2HTR1ASLC6A4
SCHEMBL4823773 0.78 DRD2 (1.00) DRD2DRD4GRM2HTR2CSLC6A4
SCHEMBL7815594 0.77 SLC6A4 (0.46) DRD2HTR1ASLC6A4CHRNA7SIGMAR1
SCHEMBL9311321 0.77 DRD2 (0.66) DRD2DRD4GRM2CHRM4HTR2C
SCHEMBL27782533 0.76 DRD2 (0.58) DRD2DRD4GRM2CHRM4HTR2C
SCHEMBL11316386 0.76 DRD2 (0.55) DRD2DRD4HTR1ASLC6A4
SCHEMBL4824740 0.76 DRD2 (0.85) DRD2DRD4GRM2HTR2CHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1357928-A4 A NOVEL PHARMACEUTICAL COMPOUND AND METHODS OF MAKING AND USING SAME NEW RIVER PHARMACEUTICALS INC (US) 2004-12-29 EP disclosed
EP-1357928-A2 A NOVEL PHARMACEUTICAL COMPOUND AND METHODS OF MAKING AND USING SAME New River Pharmaceuticals Inc. (US) 2003-11-05 EP disclosed
WO-2003020200-A2 A NOVEL PHARMACEUTICAL COMPOUND AND METHODS OF MAKING AND USING SAME NEW RIVER PHARMACEUTICALS INC. (US) 2003-03-13 WO disclosed