SCHEMBL6921157

SCHEMBL6921157

Cn1nc(C2CC2)c(C(=O)c2cccnc2)c1O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.41
HTT P42858 2/20 0.40
TSHR P16473 2/20 0.40
MAPK1 P28482 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
GAA P10253 2/20 0.40
APP P05067 1/20 0.40
HCAR3 P49019 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40
F7 P08709 1/20 0.39
F3 P13726 1/20 0.39
SARM1 Q6SZW1 1/20 0.39
SIRT2 Q8IXJ6 1/20 0.39
SIRT6 Q8N6T7 1/20 0.39
SIRT1 Q96EB6 1/20 0.39
SIRT3 Q9NTG7 1/20 0.39
SIRT5 Q9NXA8 1/20 0.39
SIRT4 Q9Y6E7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6919504 0.95 ALDH1A1 (0.41) ALDH1A1L3MBTL1SMN1; SMN2HTTTSHR
SCHEMBL6920224 0.94 ALDH1A1 (0.43) ALDH1A1L3MBTL1SMN1; SMN2HTTTSHR
SCHEMBL6920008 0.84 L3MBTL1 (0.41) ALDH1A1L3MBTL1SMN1; SMN2HTTTSHR
SCHEMBL6921251 0.80 TSHR (0.49) ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1
SCHEMBL6920431 0.79 ALDH1A1 (0.41) ALDH1A1L3MBTL1SMN1; SMN2HTTNPSR1
SCHEMBL6919778 0.76 ALDH1A1 (0.41) ALDH1A1TSHRMAPK1NPSR1GAA
SCHEMBL6918282 0.76 ALDH1A1 (0.42) ALDH1A1L3MBTL1SMN1; SMN2HTTTSHR
SCHEMBL6920743 0.76 NPC1 (0.42) ALDH1A1SMN1; SMN2TSHRMAPK1NPSR1
SCHEMBL6916106 0.75 LMNA (0.46) ALDH1A1SMN1; SMN2MAPK1GAAAPP
SCHEMBL2214214 0.74 ALDH1A1 (0.43) ALDH1A1L3MBTL1HTTTSHRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004033431-A2 HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS ARENA PHARMACEUTICALS, INC. (US) 2004-04-22 WO claimed
WO-2004033431-A2 HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS ARENA PHARMACEUTICALS, INC. (US) 2004-04-22 WO disclosed