Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | FHIT | P49789 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324231 | 0.89 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL8318915 | 0.77 | NPC1 (0.50) | ALDH1A1KDM4EMAPTSMN1; SMN2LMNA | |
| SCHEMBL8319163 | 0.74 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL8324499 | 0.73 | CNR2 (0.35) | — | |
| SCHEMBL5026641 | 0.73 | CYP19A1 (0.47) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL8320953 | 0.73 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL73099 | 0.72 | PTGDR2 (0.44) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL6755376 | 0.71 | GFER (0.50) | ALDH1A1KDM4ERXRARXRBRXRG | |
| SCHEMBL8323847 | 0.71 | TSHR (0.37) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL72465 | 0.70 | PTGDR2 (0.45) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069831-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-08-19 | — | — | WO | disclosed |