Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326243 | 0.88 | PDE4A (0.51) | NPC1RAB9AALDH1A1LMNANPSR1 | |
| SCHEMBL8325539 | 0.85 | ALDH1A1 (0.50) | NPC1RAB9AALDH1A1LMNANPSR1 | |
| SCHEMBL8325509 | 0.78 | GAA (0.49) | NPC1RAB9AALDH1A1LMNANPSR1 | |
| SCHEMBL6921360 | 0.77 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPK1TP53MAPT | |
| SCHEMBL8324668 | 0.77 | PDE4A (0.59) | NPC1RAB9AALDH1A1LMNANPSR1 | |
| SCHEMBL8327267 | 0.76 | PDE4A (0.42) | LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8318940 | 0.76 | PDE4A (0.58) | NPC1RAB9AALDH1A1LMNANPSR1 | |
| SCHEMBL8324231 | 0.76 | ALDH1A1 (0.43) | NPC1RAB9AALDH1A1MAPK1TP53 | |
| SCHEMBL6778380 | 0.73 | SGMS2 (0.76) | ALDH1A1MAPK1SGMS2 | |
| SCHEMBL8324421 | 0.73 | PDE4D (0.44) | MAPK1MAPTSMN1; SMN2TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069831-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-08-19 | — | — | WO | disclosed |