Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.35 |
| ▸ | HTR2C | P28335 | 5/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324231 | 0.84 | ALDH1A1 (0.43) | — | |
| SCHEMBL8324502 | 0.81 | PDE4A (0.33) | CYP19A1CYP11B1CYP11B2PDE4DPDE4A | |
| SCHEMBL8327267 | 0.80 | PDE4A (0.42) | KDM4CCYP19A1CYP11B1CYP11B2PDE4D | |
| SCHEMBL8319163 | 0.80 | ALDH1A1 (0.39) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8320435 | 0.80 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8320953 | 0.79 | ALDH1A1 (0.39) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8326243 | 0.77 | PDE4A (0.51) | HTR2CHTR2AKDM4CPDE4DPDE4A | |
| SCHEMBL8323847 | 0.77 | TSHR (0.37) | — | |
| SCHEMBL8325988 | 0.77 | PDE4D (0.35) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6921360 | 0.73 | ALDH1A1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069831-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-08-19 | — | — | WO | disclosed |