Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | TP53 | P04637 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11204672 | 0.82 | MAPT (0.54) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL9035469 | 0.80 | MAPT (0.52) | MAPTTP53POLBMEN1HTT | |
| SCHEMBL691641 | 0.77 | LMNA (0.39) | MAPTTP53POLBLMNASMN1; SMN2 | |
| SCHEMBL4378995 | 0.76 | MAPT (0.39) | MAPTTP53POLBLMNASMN1; SMN2 | |
| SCHEMBL6995111 | 0.76 | SMN1; SMN2 (0.59) | MAPTTP53MEN1KMT2ALMNA | |
| SCHEMBL31560851 | 0.74 | MAPT (0.48) | MAPTTP53POLBMEN1HTT | |
| SCHEMBL692238 | 0.73 | ALDH1A1 (0.36) | MAPTTP53KMT2ALMNASMN1; SMN2 | |
| SCHEMBL18470230 | 0.72 | MTNR1A (0.47) | MAPTTP53POLBMEN1HTT | |
| SCHEMBL692261 | 0.72 | BRD4 (0.46) | KMT2A | |
| SCHEMBL14564360 | 0.72 | MAPT (0.56) | MAPTTP53POLBMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2422780-A1 | Resistance-repellent retroviral protease inhibitors | Sequoia Pharmaceuticals, Inc. (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-2422781-A1 | Resistance-repellent retroviral protease inhibitors | Sequoia Pharmaceuticals, Inc. (US) | 2012-02-29 | — | — | EP | disclosed |