Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | FPR2 | P25090 | 6/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131856 | 0.87 | SCN9A (0.62) | SCN9AFPR2 | |
| SCHEMBL2543831 | 0.86 | HDAC6 (0.50) | SCN9AKMT2AMEN1MAPT | |
| SCHEMBL29383595 | 0.86 | HDAC6 (0.50) | SCN9AKMT2AMEN1MAPT | |
| SCHEMBL29961676 | 0.82 | NPC1 (0.56) | SCN9APARP10KMT2AMEN1MAPT | |
| SCHEMBL29520004 | 0.79 | SCN9A (0.53) | SCN9ACHEK2FPR2 | |
| SCHEMBL30681806 | 0.77 | LTA4H (0.49) | SCN9ATNK2KMT2AMEN1BTK | |
| SCHEMBL13729587 | 0.77 | KMT2A (0.53) | SCN9ACHEK2KMT2AMEN1MAPT | |
| SCHEMBL3129156 | 0.77 | SCN9A (0.57) | SCN9ACHEK2KMT2AMEN1FPR2 | |
| SCHEMBL13726855 | 0.77 | L3MBTL1 (0.51) | SCN9ACHEK2 | |
| SCHEMBL6741053 | 0.77 | KMT2A (0.61) | KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265866-B1 | ARYL SUBSTITUTED PYRIDINES, PYRIMIDINES, PYRAZINES AND TRIAZINES AND THE USE THEREOF | EURO CELTIQUE SA (LU) | 2010-07-21 | — | — | EP | disclosed |
| WO-2004111011-A2 | SYNTHESIS OF 2-ARYL PYRIMIDINE 4-CARBOXYLIC ACID AMIDES | EURO-CELTIQUE S.A. (LU) | 2004-12-23 | — | — | WO | disclosed |