Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6925731 | 0.99 | HRH3 (0.46) | HRH3KCNH2RPS6KB1AKT1CSNK1E | |
| SCHEMBL6926147 | 0.82 | HTR1A (0.41) | HRH3CSNK1ECYP11B2 | |
| SCHEMBL6924877 | 0.81 | PIK3C3 (0.38) | KCNH2RPS6KB1AKT1CYP11B1 | |
| SCHEMBL6924977 | 0.80 | TLR9 (0.41) | HRH3KCNH2 | |
| SCHEMBL6924980 | 0.80 | DRD2 (0.42) | KCNH2RPS6KB1AKT1 | |
| SCHEMBL6927205 | 0.80 | KCNH2 (0.40) | KCNH2CYP11B1CYP11B2 | |
| SCHEMBL6925150 | 0.78 | WNT1 (0.42) | KCNH2 | |
| SCHEMBL6921703 | 0.78 | LRRK2 (0.43) | KCNH2RPS6KB1AKT1 | |
| SCHEMBL6927914 | 0.77 | TRPV3 (0.43) | KCNH2RPS6KB1AKT1 | |
| SCHEMBL6927844 | 0.77 | HRH3 (0.43) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514966-B2 | Neuropeptide Y antagonists such as 2-chloro-5-(4-(3,4-dich loro-phenyl)-1H-imidazol-2-yl)-pyridine | PFIZER INC. | 2003-02-04 | — | — | US | disclosed |
| US-6355635-B1 | IMIDAZOLEBENZENE, IMIDAZOLEPYRIDINE COMPOUNDS FOR TREATMENT OF OBESITY | PFIZER INC. | 2002-03-12 | — | — | US | disclosed |