Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435141 | 0.76 | ALDH1A1 (0.33) | RAB9ANPC1MAPTSMN1; SMN2MGLL | |
| SCHEMBL6826584 | 0.75 | ALDH1A1 (0.36) | RAB9ANPC1SMN1; SMN2ACHEALDH1A1 | |
| SCHEMBL6599832 | 0.74 | PTGS2 (0.43) | MAPTACHEALDH1A1TDP1POLB | |
| SCHEMBL2685223 | 0.72 | HTT (0.47) | MAPTSMN1; SMN2ACHEALDH1A1TDP1 | |
| SCHEMBL3128001 | 0.71 | — | — | |
| SCHEMBL7435136 | 0.70 | ALDH1A1 (0.31) | MAPTALDH1A1TDP1 | |
| SCHEMBL8517091 | 0.69 | CYP19A1 (0.38) | RAB9ANPC1MAPTSMN1; SMN2MGLL | |
| SCHEMBL7831019 | 0.69 | KCNH2 (0.43) | MAPTESPL1ALDH1A1TDP1CYP19A1 | |
| SCHEMBL4527774 | 0.68 | CYP19A1 (0.43) | RAB9ANPC1MAPTSMN1; SMN2ACHE | |
| SCHEMBL30599160 | 0.68 | ALDH1A1 (0.41) | RAB9ANPC1MAPTSMN1; SMN2MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194143-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-1194143-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000076457-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |