Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2685223 | 0.81 | HTT (0.47) | PTGS2ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL27892992 | 0.80 | TDP1 (0.37) | ALDH1A1MAPTLMNATDP1POLB | |
| SCHEMBL655747 | 0.80 | VCAM1 (0.36) | ALDH1A1MAPTKMT2ALMNAMEN1 | |
| SCHEMBL10401592 | 0.79 | ALDH1A1 (0.35) | PTGS2ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL11854424 | 0.78 | MAPT (0.51) | ALDH1A1MAPTKMT2ALMNAMEN1 | |
| SCHEMBL16974732 | 0.78 | SIGMAR1 (0.46) | LMNATSHRCHRNB2CHRNA4 | |
| SCHEMBL4527774 | 0.77 | CYP19A1 (0.43) | ALDH1A1MAPTKMT2ALMNANPSR1 | |
| SCHEMBL4135373 | 0.75 | PTGS2 (0.47) | PTGS2ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL6922449 | 0.74 | RAB9A (0.36) | ALDH1A1MAPTTDP1POLBCYP1A2 | |
| SCHEMBL458041 | 0.74 | POLB (0.43) | ALDH1A1MAPTKMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111377907-B | Polysubstituted phenylamino pyrimidine derivative and preparation method and application thereof | 杭州百新生物医药科技有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-111377907-A | Polysubstituted phenylamino pyrimidine derivative and preparation method and application thereof | 杭州百新生物医药科技有限公司 | 2020-07-07 | — | — | CN | disclosed |
| WO-2020135507-A1 | POLYSUBSTITUTED ANILINOPYRIMIDINE DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF | 杭州百新生物医药科技有限公司 | 2020-07-02 | — | — | WO | disclosed |
| US-6800630-B2 | CYTOSTATIC ACTIVITY, INHIBITORY ACTIVITY AGAINST A SIGNAL DERIVED FROM RAS ONCOGENE PRODUCTS | SHIONOGI & CO., LTD. (JP) | 2004-10-05 | — | — | US | disclosed |
| EP-1251129-B1 | PYRIMIDINE DERIVATIVES HAVING ANTITUMOR EFFECT | SHIONOGI & CO (JP) | 2004-06-09 | — | — | EP | disclosed |
| US-20030203894-A1 | Pyrimidine derivatives having antitumor effect | SHIONOGI & CO., LTD. (JP) | 2003-10-30 | — | — | US | disclosed |
| EP-1251129-A1 | PYRIMIDINE DERIVATIVES HAVING ANTITUMOR EFFECT | SHIONOGI & CO., LTD. (JP) | 2002-10-23 | — | — | EP | disclosed |
| US-6420367-B1 | RAS GENE | SHIONOGO & CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1097933-A1 | PYRIMIDINE DERIVATIVES EXHIBITING ANTITUMOR ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2001-05-09 | — | — | EP | disclosed |
| US-4137273-A | INSECTICIDES, CHEMICAL INTERMEDIATES | ZOECON CORPORATION (US) | 1979-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203894-A1 | Pyrimidine derivatives having antitumor effect | TYMS, TYMP, RRM1 | PTGS2 3500/4885ALDH1A1 1562/4885MAPT 4564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.