Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FSCN1 | Q16658 | 3/20 | 0.54 |
| ▸ | PHOSPHO1 | Q8TCT1 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | EP300 | Q09472 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | G6PD | P11413 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | MPI | P34949 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691991 | 0.91 | FSCN1 (0.54) | FSCN1PHOSPHO1MEN1KMT2AEP300 | |
| SCHEMBL691993 | 0.88 | VCP (0.46) | FSCN1PHOSPHO1MEN1KMT2AEP300 | |
| SCHEMBL693068 | 0.84 | FSCN1 (0.45) | FSCN1PHOSPHO1MEN1KMT2AEP300 | |
| SCHEMBL691978 | 0.82 | FSCN1 (0.48) | FSCN1PHOSPHO1MEN1KMT2AALDH1A1 | |
| SCHEMBL13865694 | 0.81 | FSCN1 (0.64) | FSCN1PHOSPHO1MEN1KMT2AEP300 | |
| Bromide SCHEMBL4800288 | 0.81 | PHOSPHO1 (0.49) | FSCN1PHOSPHO1MEN1KMT2AALDH1A1 | |
| SCHEMBL12632697 | 0.71 | FSCN1 (1.00) | FSCN1PHOSPHO1MEN1KMT2AEP300 | |
| SCHEMBL15625676 | 0.67 | FSCN1 (0.65) | FSCN1PHOSPHO1MEN1KMT2AEP300 | |
| SCHEMBL10480096 | 0.63 | MAPT (0.71) | MEN1KMT2AALDH1A1LMNAGAA | |
| SCHEMBL6264546 | 0.63 | AGPAT2 (0.50) | ALDH1A1LMNAGAAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501791-B2 | 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARAMACEUTICAL, INC. (US) | 2013-08-06 | — | — | US | claimed |
| US-20100280079-A1 | 0NOVEL, 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | EISINGER MAGDALENA | 2010-11-04 | — | — | US | claimed |
| US-20090203751-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | EISINGER MAGDALENA EISINGER | 2009-08-13 | — | — | US | claimed |
| EP-1444215-B1 | 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | ORTHO MCNEIL PHARM INC (US) | 2006-07-19 | — | — | EP | claimed |
| US-20060030604-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ELSINGER MAGDALENA | 2006-02-09 | — | — | US | claimed |
| EP-1444215-A1 | NOVEL 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | Ortho-Mcneil Pharmaceutical Corp. (US) | 2004-08-11 | — | — | EP | claimed |
| US-20030162819-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-08-28 | — | — | US | claimed |
| WO-2003040118-A1 | NOVEL 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-05-15 | — | — | WO | claimed |
| US-20130210868-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICAL, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-20130203823-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICAL, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-8501791-B2 | 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARAMACEUTICAL, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501791-B2 | 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARAMACEUTICAL, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| EP-2421521-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | Janssen Pharmaceuticals, Inc. (US) | 2012-02-29 | — | — | EP | disclosed |
| US-20100280079-A1 | 0NOVEL, 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | EISINGER MAGDALENA | 2010-11-04 | — | — | US | disclosed |
| EP-1444215-B1 | 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | ORTHO MCNEIL PHARM INC (US) | 2006-07-19 | — | — | EP | disclosed |
| US-20060128772-A1 | Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators | EISINGER MAGDALENA | 2006-06-15 | — | — | US | disclosed |
| US-7049331-B2 | 1,2,4-thiadiazole derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-05-23 | — | — | US | disclosed |
| US-20060030604-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ELSINGER MAGDALENA | 2006-02-09 | — | — | US | disclosed |
| US-20030176425-A1 | Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-09-18 | — | — | US | disclosed |
| US-20030162819-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176425-A1 | Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2870/4885PHOSPHO1 3808/4885MEN1 1380/4885 |
| US-20030162819-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2848/4885PHOSPHO1 3651/4885MEN1 1967/4885 |
| US-20060030604-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2848/4885PHOSPHO1 3651/4885MEN1 1967/4885 |
| US-20130203823-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | MC1R, MC5R, MC4R | FSCN1 4129/4885PHOSPHO1 1638/4885MEN1 2282/4885 |
| US-20100280079-A1 | 0NOVEL, 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | MC1R, MC5R, MC3R | FSCN1 2652/4885PHOSPHO1 2288/4885MEN1 2019/4885 |
| US-20130210868-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | MC1R, MC5R, MC4R | FSCN1 4129/4885PHOSPHO1 1638/4885MEN1 2282/4885 |
| US-20060128772-A1 | Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2870/4885PHOSPHO1 3808/4885MEN1 1380/4885 |
| US-20090203751-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2848/4885PHOSPHO1 3651/4885MEN1 1967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.