Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FSCN1 | Q16658 | 3/20 | 0.45 |
| ▸ | PHOSPHO1 | Q8TCT1 | 3/20 | 0.44 |
| ▸ | EP300 | Q09472 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692310 | 0.84 | FSCN1 (0.54) | FSCN1PHOSPHO1EP300ALDH1A1MEN1 | |
| SCHEMBL691991 | 0.81 | FSCN1 (0.54) | FSCN1PHOSPHO1EP300ALDH1A1MEN1 | |
| SCHEMBL13865655 | 0.81 | FSCN1 (0.63) | FSCN1PHOSPHO1EP300ALDH1A1MEN1 | |
| SCHEMBL691886 | 0.80 | MAPT (0.47) | ALDH1A1MEN1LMNAPKMKMT2A | |
| SCHEMBL691978 | 0.75 | FSCN1 (0.48) | FSCN1PHOSPHO1ALDH1A1MEN1LMNA | |
| Bromide SCHEMBL4800288 | 0.74 | PHOSPHO1 (0.49) | FSCN1PHOSPHO1ALDH1A1MEN1LMNA | |
| SCHEMBL5451204 | 0.65 | MAPT (0.58) | ALDH1A1LMNAKMT2AGAAMAPT | |
| SCHEMBL13865694 | 0.65 | FSCN1 (0.64) | FSCN1PHOSPHO1EP300ALDH1A1MEN1 | |
| SCHEMBL1823412 | 0.62 | RAB9A (0.75) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL3406539 | 0.62 | ALOX5 (0.81) | ALDH1A1MEN1PKMKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501791-B2 | 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARAMACEUTICAL, INC. (US) | 2013-08-06 | — | — | US | claimed |
| US-20100280079-A1 | 0NOVEL, 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | EISINGER MAGDALENA | 2010-11-04 | — | — | US | claimed |
| US-20090203751-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | EISINGER MAGDALENA EISINGER | 2009-08-13 | — | — | US | claimed |
| EP-1444215-B1 | 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | ORTHO MCNEIL PHARM INC (US) | 2006-07-19 | — | — | EP | claimed |
| US-20060030604-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ELSINGER MAGDALENA | 2006-02-09 | — | — | US | claimed |
| EP-1444215-A1 | NOVEL 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | Ortho-Mcneil Pharmaceutical Corp. (US) | 2004-08-11 | — | — | EP | claimed |
| US-20030162819-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-08-28 | — | — | US | claimed |
| WO-2003040118-A1 | NOVEL 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-05-15 | — | — | WO | claimed |
| US-20130210868-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICAL, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-20130203823-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICAL, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| EP-2421521-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | Janssen Pharmaceuticals, Inc. (US) | 2012-02-29 | — | — | EP | disclosed |
| US-20100273838-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | Janssen Pharmaceuticals, Inc. | 2010-10-28 | — | — | US | disclosed |
| WO-2010124175-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162819-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2848/4885PHOSPHO1 3651/4885EP300 355/4885 |
| US-20060030604-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2848/4885PHOSPHO1 3651/4885EP300 355/4885 |
| US-20130203823-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | MC1R, MC5R, MC4R | FSCN1 4129/4885PHOSPHO1 1638/4885EP300 3424/4885 |
| US-20100280079-A1 | 0NOVEL, 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | MC1R, MC5R, MC3R | FSCN1 2652/4885PHOSPHO1 2288/4885EP300 745/4885 |
| US-20130210868-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | MC1R, MC5R, MC4R | FSCN1 4129/4885PHOSPHO1 1638/4885EP300 3424/4885 |
| US-20100273838-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | MC1R, MC5R, MC4R | FSCN1 4129/4885PHOSPHO1 1638/4885EP300 3424/4885 |
| US-20090203751-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2848/4885PHOSPHO1 3651/4885EP300 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.