Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FSCN1 | Q16658 | 1/20 | 0.48 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4800288 | 0.99 | PHOSPHO1 (0.49) | FSCN1PHOSPHO1VCPHPGDSCYP1A2 | |
| SCHEMBL691993 | 0.92 | VCP (0.46) | FSCN1PHOSPHO1VCPHPGDSCYP1A2 | |
| SCHEMBL691886 | 0.88 | MAPT (0.47) | VCPLMNAALOX15HSD17B10MEN1 | |
| SCHEMBL691991 | 0.82 | FSCN1 (0.54) | FSCN1PHOSPHO1LMNAMEN1KMT2A | |
| SCHEMBL692310 | 0.82 | FSCN1 (0.54) | FSCN1PHOSPHO1VCPHPGDSLMNA | |
| SCHEMBL693068 | 0.75 | FSCN1 (0.45) | FSCN1PHOSPHO1LMNAMEN1KMT2A | |
| SCHEMBL19219203 | 0.66 | CDK9 (0.57) | VCPHPGDSCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12632697 | 0.65 | FSCN1 (1.00) | FSCN1PHOSPHO1LMNAMEN1KMT2A | |
| SCHEMBL21670529 | 0.64 | CYP1A2 (0.49) | VCPHPGDSCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12297184 | 0.64 | VCP (0.79) | VCPHPGDSCYP1A2LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130210868-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICAL, INC. (US) | 2013-08-15 | — | — | US | claimed |
| US-8501791-B2 | 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARAMACEUTICAL, INC. (US) | 2013-08-06 | — | — | US | claimed |
| EP-2421521-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | Janssen Pharmaceuticals, Inc. (US) | 2012-02-29 | — | — | EP | claimed |
| US-20100280079-A1 | 0NOVEL, 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | EISINGER MAGDALENA | 2010-11-04 | — | — | US | claimed |
| WO-2010124175-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) | 2010-10-28 | — | — | WO | claimed |
| US-20100273838-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | Janssen Pharmaceuticals, Inc. | 2010-10-28 | — | — | US | claimed |
| US-20090203751-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | EISINGER MAGDALENA EISINGER | 2009-08-13 | — | — | US | claimed |
| US-7319107-B2 | 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) | 2008-01-15 | — | — | US | claimed |
| EP-1444215-B1 | 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | ORTHO MCNEIL PHARM INC (US) | 2006-07-19 | — | — | EP | claimed |
| US-20060030604-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ELSINGER MAGDALENA | 2006-02-09 | — | — | US | claimed |
| EP-1444215-A1 | NOVEL 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | Ortho-Mcneil Pharmaceutical Corp. (US) | 2004-08-11 | — | — | EP | claimed |
| US-20030162819-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-08-28 | — | — | US | claimed |
| WO-2003040118-A1 | NOVEL 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-05-15 | — | — | WO | claimed |
| US-20130210868-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICAL, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| US-20130203823-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICAL, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203823-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICAL, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-7049331-B2 | 1,2,4-thiadiazole derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-05-23 | — | — | US | disclosed |
| US-20060030604-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ELSINGER MAGDALENA | 2006-02-09 | — | — | US | disclosed |
| US-20030176425-A1 | Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-09-18 | — | — | US | disclosed |
| US-20030162819-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176425-A1 | Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2870/4885PHOSPHO1 3808/4885VCP 3685/4885 |
| US-20030162819-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2848/4885PHOSPHO1 3651/4885VCP 3429/4885 |
| US-20060030604-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2848/4885PHOSPHO1 3651/4885VCP 3429/4885 |
| US-20130203823-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | MC1R, MC5R, MC4R | FSCN1 4129/4885PHOSPHO1 1638/4885VCP 4323/4885 |
| US-20100280079-A1 | 0NOVEL, 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | MC1R, MC5R, MC3R | FSCN1 2652/4885PHOSPHO1 2288/4885VCP 3511/4885 |
| US-20130210868-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | MC1R, MC5R, MC4R | FSCN1 4129/4885PHOSPHO1 1638/4885VCP 4323/4885 |
| US-20100273838-A1 | STABLE TOPICAL COMPOSITIONS FOR 1,2,4-THIADIAZOLE DERIVATIVES | MC1R, MC5R, MC4R | FSCN1 4129/4885PHOSPHO1 1638/4885VCP 4323/4885 |
| US-20090203751-A1 | Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | MC1R, MC5R, MC3R | FSCN1 2848/4885PHOSPHO1 3651/4885VCP 3429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.