Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.49 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691978 | 0.99 | FSCN1 (0.48) | PHOSPHO1FSCN1VCPHPGDSCYP1A2 | |
| SCHEMBL691993 | 0.91 | VCP (0.46) | PHOSPHO1FSCN1VCPHPGDSCYP1A2 | |
| SCHEMBL691886 | 0.86 | MAPT (0.47) | VCPLMNAALOX15HSD17B10MEN1 | |
| SCHEMBL691991 | 0.81 | FSCN1 (0.54) | PHOSPHO1FSCN1LMNAMEN1KMT2A | |
| SCHEMBL692310 | 0.81 | FSCN1 (0.54) | PHOSPHO1FSCN1VCPHPGDSLMNA | |
| SCHEMBL693068 | 0.74 | FSCN1 (0.45) | PHOSPHO1FSCN1LMNAMEN1KMT2A | |
| SCHEMBL19219203 | 0.65 | CDK9 (0.57) | VCPHPGDSCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12632697 | 0.65 | FSCN1 (1.00) | PHOSPHO1FSCN1LMNAMEN1KMT2A | |
| SCHEMBL21670529 | 0.63 | CYP1A2 (0.49) | VCPHPGDSCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12297184 | 0.63 | VCP (0.79) | VCPHPGDSCYP1A2LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319107-B2 | 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) | 2008-01-15 | — | — | US | claimed |