SCHEMBL6923121

SCHEMBL6923121

Cc1cc(CO)cc2c1nc(C)n2C(C)c1ccc(-c2ccccc2)cc1Cl

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DCTPP1 Q9H773 3/20 0.36
DHODH Q02127 1/20 0.33
ESR2 Q92731 1/20 0.32
PPARG P37231 2/20 0.31
S1PR1 P21453 1/20 0.31
S1PR3 Q99500 1/20 0.31
AGTR1 P30556 2/20 0.31
PPARA Q07869 1/20 0.30
PDE5A O76074 1/20 0.30
PDE2A O00408 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6492577 0.77 DCTPP1 (0.41) DCTPP1
SCHEMBL6923116 0.76 DCTPP1 (0.36) DCTPP1DHODHPPARGAGTR1
SCHEMBL6923118 0.76 DHODH (0.33) DCTPP1DHODHESR2PDE5A
SCHEMBL27622096 0.64 ALDH1A1 (0.47) ESR2PPARGPPARA
SCHEMBL6498493 0.64 DCTPP1 (0.40) DCTPP1ESR2PPARG
SCHEMBL19078687 0.63 ESR2 (0.52) ESR2S1PR1S1PR3
SCHEMBL7712898 0.63 PDE10A (0.50) DCTPP1
SCHEMBL6486764 0.62 DCTPP1 (0.44) DCTPP1DHODHPPARGAGTR1
SCHEMBL6490602 0.62 PPARG (0.41) DCTPP1PPARG
SCHEMBL8546094 0.60 ESR2 (0.48) ESR2S1PR1S1PR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004108686-A2 BENZIMIDAZOLE COMPOUNDS HAVING HYPOGLYCEMIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-12-16 WO disclosed