Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.39 |
| ▸ | GLRB | P48167 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21793858 | 0.79 | CCNA2 (0.42) | DHPSCDK2CCNA2CCNA1AXL | |
| SCHEMBL8062076 | 0.77 | CCNA2 (0.43) | CDK2CCNA2CCNA1AXLIDO1 | |
| SCHEMBL29705820 | 0.76 | NOS1 (0.49) | CDK2CCNA2CCNA1AXLCCNE1 | |
| SCHEMBL6923181 | 0.76 | NOS1 (0.49) | CDK2CCNA2CCNA1AXLIDO1 | |
| SCHEMBL5446861 | 0.76 | CCNA2 (0.42) | CDK2CCNA2CCNA1AXLTRPA1 | |
| SCHEMBL20132550 | 0.75 | AXL (0.43) | DHPSCDK2CCNA2CCNA1AXL | |
| SCHEMBL21100786 | 0.73 | TRPA1 (0.51) | DHPSCDK2CCNA2CCNA1AXL | |
| SCHEMBL14804208 | 0.73 | NOS1 (0.46) | DHPSCDK2AXLTRPA1IDO1 | |
| SCHEMBL21341661 | 0.71 | AXL (0.44) | DHPSCDK2CCNA2CCNA1AXL | |
| SCHEMBL22967876 | 0.71 | AXL (0.56) | CDK2CCNA1AXLTRPV1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834424-B2 | Compounds useful as chaperone-mediated autophagy modulators | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2023-12-05 | — | — | US | disclosed |
| US-11834424-B2 | Compounds useful as chaperone-mediated autophagy modulators | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2023-12-05 | — | — | US | disclosed |
| US-20210317095-A1 | COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11834424-B2 | Compounds useful as chaperone-mediated autophagy modulators | SQSTM1, HSPA5, ATG7 | DHPS 3877/4885CDK2 3663/4885CCNA2 4079/4885 |
| US-20210317095-A1 | COMPOUNDS USEFUL AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS | SQSTM1, HSPA5, ATG7 | DHPS 3877/4885CDK2 3663/4885CCNA2 4079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.