Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.51 |
| ▸ | SLC5A1 | P13866 | 4/20 | 0.50 |
| ▸ | SLC5A2 | P31639 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24841623 | 0.84 | CYP19A1 (0.70) | MAPTHPGDMEN1KMT2ACYP3A4 | |
| SCHEMBL5036945 | 0.80 | MAPT (0.77) | MAPTHPGDMEN1KMT2ACYP3A4 | |
| SCHEMBL8578359 | 0.79 | MAPT (0.55) | MAPTHPGDMEN1KMT2ACYP3A4 | |
| SCHEMBL134713 | 0.77 | GAA (0.68) | MAPTHPGDGAALMNAALDH1A1 | |
| SCHEMBL1245802 | 0.76 | GAA (0.83) | MAPTHPGDMEN1KMT2ACYP3A4 | |
| SCHEMBL29535946 | 0.76 | GAA (0.83) | MAPTHPGDMEN1KMT2ACYP3A4 | |
| SCHEMBL11627675 | 0.76 | SLC5A1 (0.71) | MAPTHPGDMEN1KMT2ACYP3A4 | |
| SCHEMBL27697248 | 0.76 | MAPT (0.60) | MAPTHPGDMEN1KMT2ACYP3A4 | |
| SCHEMBL11628971 | 0.76 | SLC5A1 (0.71) | MAPTHPGDMEN1KMT2ACYP3A4 | |
| SCHEMBL5271301 | 0.75 | HDAC1 (0.53) | MAPTHPGDGAALMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518301-B1 | Better selectivity than estrogen for the estrogen receptor-beta over receptor-alpha; treatment of Alzheimer's disease, anxiety, depression, osteoporosis, cardiovascular disease, rheumatoid arthritis, or prostate cancer | ASTRAZENECA AB (SE) | 2003-02-11 | — | — | US | disclosed |
| EP-1173164-A2 | ESTROGEN RECEPTOR-BETA LIGANDS | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000062765-A2 | ESTROGEN RECEPTOR-β LIGANDS | ASTRAZENECA AB (SE) | 2000-10-26 | — | — | WO | disclosed |