Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20383970 | 0.88 | LMNA (0.50) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL3547431 | 0.79 | HTR1A (0.45) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL4543187 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL6929872 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL7316505 | 0.77 | ALDH1A1 (0.74) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL18779432 | 0.77 | ALDH1A1 (0.74) | ALDH1A1MAPTLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL10886708 | 0.76 | CSNK2A2 (0.54) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL18779472 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL18779398 | 0.74 | MEN1 (0.74) | KDM4EALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL11577961 | 0.73 | CSNK2A1 (0.52) | KDM4EALDH1A1MAPTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |