Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.78 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.78 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.78 |
| ▸ | ANPEP | P15144 | 5/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927281 | 0.88 | DPP4 (1.00) | DPP4NR1H2NR1H3ANPEPFAAH | |
| SCHEMBL29366407 | 0.77 | DPP4 (0.78) | DPP4NR1H2NR1H3ANPEPFAAH | |
| SCHEMBL2820118 | 0.77 | DPP4 (0.78) | DPP4NR1H2NR1H3ANPEPFAAH | |
| SCHEMBL12055788 | 0.74 | DPP4 (0.48) | DPP4NR1H2NR1H3ANPEPCYP1A2 | |
| SCHEMBL9612014 | 0.73 | DPP4 (0.63) | DPP4NR1H2NR1H3ANPEPGABRA1 | |
| SCHEMBL28152643 | 0.69 | DPP4 (0.46) | DPP4NR1H2NR1H3ANPEPGABRA1 | |
| SCHEMBL167078 | 0.69 | GABRA1 (0.55) | DPP4NR1H2NR1H3GABRA1FAAH | |
| SCHEMBL29414063 | 0.69 | GABRA1 (0.55) | DPP4NR1H2NR1H3GABRA1FAAH | |
| SCHEMBL2032898 | 0.68 | MGLL (0.63) | DPP4NR1H2NR1H3ANPEPGABRA1 | |
| SCHEMBL300362 | 0.68 | DPP4 (0.61) | DPP4NR1H2NR1H3ANPEPHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515129-B1 | A pharmaceutical composition which comprises, a cyclic imide derivative represented by the general formula (I): present invention relates to an aminopeptidase N inhibitor or an angiogenesis inhibitor, modulates production of tumor necrosis | ISHIHARA SANGYO KAISHA LTD. (JP) | 2003-02-04 | — | — | US | disclosed |
| US-6429212-B1 | AMINOPEPTIDASE N INHIBITOR USED TO TREAT CANCER, TUMORS, AND RETINOPATHY; FEW SIDE EFFECTS; ANGIOGENESIS INHIBITOR | ISHIHARA SANGYO KAISHA LTD. (JP) | 2002-08-06 | — | — | US | disclosed |