Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | BRD1 | O95696 | 2/20 | 0.36 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820427 | 0.85 | HTR2C (0.34) | BRPF1BRD4BRD1BRPF3HTR2C | |
| SCHEMBL6930423 | 0.82 | HTR6 (0.43) | ALDH1A1HSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL6933310 | 0.71 | HTR1A (0.38) | ALDH1A1HTTLMNASLC6A4 | |
| SCHEMBL6820490 | 0.66 | TMEM97 (0.36) | BRD4ALDH1A1HTTLMNASLC6A2 | |
| SCHEMBL8162682 | 0.64 | DRD2 (0.35) | HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6816875 | 0.64 | DRD2 (0.35) | HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6816417 | 0.64 | DRD2 (0.35) | ALDH1A1HTTLMNAHTR2ASLC6A2 | |
| SCHEMBL6931978 | 0.62 | RAD52 (0.38) | HTR2CHTR2AHTR2B | |
| SCHEMBL6931982 | 0.62 | RAD52 (0.38) | HTR2CHTR2AHTR2B | |
| SCHEMBL6931976 | 0.62 | RAD52 (0.38) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025096-B1 | SUBSTITUTED CHROMAN DERIVATIVES | ASTRAZENECA AB (SE) | 2003-11-26 | — | — | EP | disclosed |
| US-6387899-B1 | ANTISEROTONINE AGENTS; ANTIDEPRESSANTS | ASTRAZENECA AB (SE) | 2002-05-14 | — | — | US | disclosed |
| US-6384225-B1 | 5-PIPERIDINYL- OR PIPERAZINYL-SUBSTITUTED 3,4-DIHYDRO-2H-1-BENZOPYRANS | ASTRAZENECA AB (SE) | 2002-05-07 | — | — | US | disclosed |