Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6933310 | 0.89 | HTR1A (0.38) | HTR6ALDH1A1LMNAKDM4ETMEM97 | |
| SCHEMBL6820490 | 0.83 | TMEM97 (0.36) | HTR6ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL8162682 | 0.82 | DRD2 (0.35) | HTR6MEN1KMT2ATMEM97SIGMAR1 | |
| SCHEMBL6816875 | 0.82 | DRD2 (0.35) | HTR6MEN1KMT2ATMEM97SIGMAR1 | |
| SCHEMBL6924865 | 0.82 | BRPF1 (0.36) | ALDH1A1LMNASMN1; SMN2HSP90AA1MAPT | |
| SCHEMBL6816417 | 0.82 | DRD2 (0.35) | HTR6ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4830529 | 0.76 | KCNH2 (0.44) | TMEM97SIGMAR1 | |
| SCHEMBL4837491 | 0.76 | KCNH2 (0.44) | TMEM97SIGMAR1 | |
| SCHEMBL8064360 | 0.70 | ALDH1A1 (0.38) | ALDH1A1LMNAMEN1KMT2AKDM4E | |
| SCHEMBL4222382 | 0.69 | DRD2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025096-B1 | SUBSTITUTED CHROMAN DERIVATIVES | ASTRAZENECA AB (SE) | 2003-11-26 | — | — | EP | disclosed |
| US-6387899-B1 | ANTISEROTONINE AGENTS; ANTIDEPRESSANTS | ASTRAZENECA AB (SE) | 2002-05-14 | — | — | US | disclosed |
| US-6384225-B1 | 5-PIPERIDINYL- OR PIPERAZINYL-SUBSTITUTED 3,4-DIHYDRO-2H-1-BENZOPYRANS | ASTRAZENECA AB (SE) | 2002-05-07 | — | — | US | disclosed |