Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ERN1 | O75460 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926210 | 0.81 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1KMT2AMEN1KDM4E | |
| SCHEMBL520702 | 0.78 | KDM4E (0.69) | ALDH1A1KMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL6926310 | 0.78 | PTGES (0.56) | ALDH1A1KMT2AMEN1LMNAERN1 | |
| SCHEMBL6926307 | 0.76 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1LMNASMN1; SMN2ERN1 | |
| SCHEMBL6926312 | 0.76 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1LMNASMN1; SMN2ERN1 | |
| SCHEMBL6927792 | 0.76 | ERN1 (0.56) | ALDH1A1KMT2AMEN1ERN1GAA | |
| SCHEMBL6922508 | 0.73 | PDE7A (0.55) | L3MBTL1ERN1CYP2C9GAAPTGES | |
| SCHEMBL6927608 | 0.73 | GAA (0.52) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL6929731 | 0.73 | GAA (0.69) | ALDH1A1L3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL6929722 | 0.73 | GAA (0.55) | ALDH1A1KMT2AMEN1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |