Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.55 |
| ▸ | MAOA | P21397 | 4/20 | 0.55 |
| ▸ | CTSV | O60911 | 3/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | HPD | P32754 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316102 | 0.83 | MAPKAPK2 (0.55) | MAOBMAOACTSVCTSLMAPKAPK2 | |
| SCHEMBL8316089 | 0.80 | MAPKAPK2 (0.55) | MAOBMAOACTSVCTSLMAPKAPK2 | |
| SCHEMBL6925320 | 0.78 | KDR (0.70) | BRD4TDP1KDM4EALDH1A1LMNA | |
| SCHEMBL5097222 | 0.78 | MAOA (0.57) | MAOBMAOACTSVCTSLMAPKAPK2 | |
| SCHEMBL31153237 | 0.73 | MCHR1 (0.61) | MAOBMAOACTSVCTSLMAPKAPK2 | |
| SCHEMBL8314677 | 0.73 | MAOB (0.51) | MAOBMAOACTSVCTSLMAPKAPK2 | |
| SCHEMBL25634129 | 0.73 | MCHR1 (0.61) | MAOBMAOACTSVCTSLMAPKAPK2 | |
| SCHEMBL2220752 | 0.73 | DYRK1A (0.58) | CHEK1KDM4EALDH1A1LMNA | |
| SCHEMBL31027151 | 0.73 | DYRK1A (0.58) | CHEK1KDM4EALDH1A1LMNA | |
| SCHEMBL2978779 | 0.72 | LMNA (0.63) | MAOBMAOACTSVCTSLMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219193-B1 | TETRAHYDROCARBAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1992-05-27 | — | — | EP | disclosed |
| US-4725615-A | SELECTIVE FOR \"NEURONAL\" 5-HYDROXYTRYPTAMINE RECEPTORS; NERVOUS SYSTEM DISORDERS | GLAXO GROUP LIMITED | 1988-02-16 | — | — | US | disclosed |
| EP-0219193-A1 | Tetrahydrocarbazolone derivatives, processes for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1987-04-22 | — | — | EP | disclosed |