Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methaniazide SCHEMBL606355 | 0.83 | ALDH1A1 (0.60) | HDAC3HDAC1HDAC2ALDH1A1HPGD | |
| SCHEMBL2998521 | 0.80 | HDAC3 (0.68) | HDAC3HDAC1HDAC2ALDH1A1HPGD | |
| SCHEMBL3001447 | 0.78 | HDAC3 (0.81) | HDAC3HDAC1HDAC2ALDH1A1CYP1A2 | |
| SCHEMBL2990093 | 0.77 | HDAC3 (0.91) | HDAC3HDAC1HDAC2ALDH1A1GAA | |
| Metazide SCHEMBL2109857 | 0.77 | ALDH1A1 (0.72) | HDAC3HDAC1HDAC2ALDH1A1HPGD | |
| SCHEMBL7401272 | 0.77 | HDAC3 (0.64) | HDAC3HDAC1HDAC2ALDH1A1CYP1A2 | |
| SCHEMBL2998122 | 0.76 | HDAC3 (0.88) | HDAC3HDAC1HDAC2GAANAAA | |
| SCHEMBL17141675 | 0.75 | HDAC3 (1.00) | HDAC3HDAC1HDAC2ALDH1A1GAA | |
| SCHEMBL2992964 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HPGDCYP1A2CYP2C19TP53 | |
| SCHEMBL2992165 | 0.74 | ALDH1A1 (0.67) | ALDH1A1HPGDCYP1A2CYP2C19TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051655-A4 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1051655-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | Ista Pharmaceuticals, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999039238-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | KERATOFORM, INC. (US) | 1999-08-05 | — | — | WO | disclosed |