Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 4/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22730588 | 0.84 | PDE4D (0.41) | TRAP1HSP90B1DPP8DPP9DPP7 | |
| SCHEMBL12765385 | 0.78 | CYP1A2 (0.42) | TRAP1TSHRKMT2AMEN1 | |
| SCHEMBL23505868 | 0.78 | TRAP1 (0.42) | TRAP1 | |
| SCHEMBL1301328 | 0.77 | NOTUM (0.44) | TRAP1HSP90B1KMT2AMEN1PKM | |
| SCHEMBL29008582 | 0.75 | ALDH1A1 (0.34) | KMT2AMEN1PKMDRD2 | |
| SCHEMBL23505873 | 0.74 | TRPA1 (0.42) | TSHRKCNH2SIGMAR1KMT2AMEN1 | |
| SCHEMBL25234740 | 0.74 | RAB9A (0.34) | L3MBTL1 | |
| SCHEMBL14626026 | 0.74 | PDE4D (0.47) | TRAP1HSP90B1TIPARPDRD2DRD3 | |
| SCHEMBL30970493 | 0.74 | RAB9A (0.34) | L3MBTL1 | |
| SCHEMBL8217297 | 0.74 | TRAP1 (0.53) | TRAP1HSP90B1DPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011109551-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-09-09 | — | — | WO | disclosed |
| EP-2305698-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2007015824-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2007-02-08 | — | — | WO | disclosed |