Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.58 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29108469 | 0.90 | CYP46A1 (0.65) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL30640092 | 0.90 | CYP46A1 (0.65) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL5740654 | 0.86 | CYP46A1 (0.64) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL5905310 | 0.84 | SLC6A3 (0.63) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL27880534 | 0.83 | PDCD1 (0.50) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL28296099 | 0.83 | SMN1; SMN2 (0.53) | ALDH1A1KDM4EGAAMAPK1KMT2A | |
| Isoquinoline SCHEMBL28038146 | 0.83 | SLC6A3 (0.58) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL6641437 | 0.81 | ALDH1A1 (0.50) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL2222831 | 0.81 | ALDH1A1 (0.50) | CYP46A1ALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL29644805 | 0.81 | KMT2A (0.61) | ALDH1A1KDM4EGLAGAASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515011-B2 | Anticoagulants | MERCK & CO., INC. | 2003-02-04 | — | — | US | disclosed |
| US-20020119992-A1 | Thrombin inhibitors | MERCK & CO., INC. | 2002-08-29 | — | — | US | disclosed |
| WO-2002050056-A1 | BENZYLAMINE DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-06-27 | — | — | WO | disclosed |
| US-4904675-A | Phamacologically active 5-carboxy-2-(5-tetrazolyl) pyridines | ZYMA SA (CH) | 1990-02-27 | — | — | US | disclosed |
| EP-0278908-A2 | Heterocyclic compounds | Zyma SA (CH) | 1988-08-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020119992-A1 | Thrombin inhibitors | SERPINC1, F2, TFPI | FGFR1 2986/4885SRC 782/4885FGFR2 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.