Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | PHGDH | O43175 | 4/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799883 | 0.87 | KMT2A (0.50) | RXFP1ACLYAHRPHGDHCYP19A1 | |
| SCHEMBL22004113 | 0.82 | ACLY (0.60) | RXFP1ACLYAHRPHGDHCYP19A1 | |
| SCHEMBL31400972 | 0.79 | ACLY (0.51) | RXFP1ACLYPHGDHCYP19A1KMT2A | |
| SCHEMBL3381195 | 0.79 | ACLY (0.51) | RXFP1ACLYPHGDHCYP19A1KMT2A | |
| SCHEMBL22004299 | 0.78 | ACLY (0.59) | RXFP1ACLYAHRPHGDH | |
| SCHEMBL8942357 | 0.77 | KMT2A (0.66) | ACLYPHGDHCYP19A1KMT2AMEN1 | |
| SCHEMBL11686956 | 0.76 | KMT2A (0.46) | RXFP1CYP19A1KMT2A | |
| SCHEMBL6707155 | 0.76 | MAPT (0.46) | RXFP1ACLYLMNAL3MBTL1 | |
| SCHEMBL22021620 | 0.75 | ACLY (0.50) | ACLYCYP19A1KMT2AL3MBTL1 | |
| SCHEMBL17199055 | 0.75 | BRPF1 (0.47) | RXFP1AHRPTGESCYP19A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518273-B1 | 2-aryl indole derivative as antagonists of tachykinins | MERCK SHARP & DOHME LTD. | 2003-02-11 | — | — | US | disclosed |
| WO-2000051984-A1 | 2-ARYL INDOLE DERIVATIVES AS ANTAGONISTS OF TACHYKININS | MERCK SHARP & DOHME LIMITED (GB) | 2000-09-08 | — | — | WO | disclosed |