Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 12/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 12/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18314460 | 0.84 | TRPV4 (0.38) | TRPV4 | |
| SCHEMBL8143451 | 0.83 | SNCA (0.37) | — | |
| SCHEMBL7715279 | 0.81 | DAO (0.43) | TRPV4CYP11B1CYP11B2DAOCACNA1H | |
| SCHEMBL19387960 | 0.79 | TRPV4 (0.47) | TRPV4CYP11B1CYP11B2DAOCACNA1H | |
| SCHEMBL4074377 | 0.78 | APLNR (0.33) | — | |
| SCHEMBL2596478 | 0.78 | ALDH1A1 (0.36) | — | |
| SCHEMBL8003064 | 0.77 | TRPV4 (0.40) | TRPV4CYP11B1CYP11B2DAOCNR1 | |
| SCHEMBL31605567 | 0.77 | TRPV4 (0.52) | TRPV4CYP11B1CYP11B2DAOCNR1 | |
| SCHEMBL16892292 | 0.77 | TRPV4 (0.52) | TRPV4CYP11B1CYP11B2DAOCNR1 | |
| SCHEMBL481069 | 0.76 | CACNA1H (0.34) | CYP11B1CYP11B2CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135023-A4 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | LILLY CO ELI (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1135023-A1 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | ELI LILLY AND COMPANY (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000027199-A1 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | ELI LILLY AND COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |