SCHEMBL6928612

SCHEMBL6928612

O=Cc1ccc(Oc2ccc(Br)cc2)cc1.Oc1ccc(Br)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH5A1 P51649 1/20 0.59
ABAT P80404 1/20 0.59
ESR1 P03372 2/20 0.52
ESR2 Q92731 2/20 0.52
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
PARP10 Q53GL7 2/20 0.51
PARP3 Q9Y6F1 1/20 0.51
ALOX15 P16050 1/20 0.48
LTA4H P09960 3/20 0.45
NR1H2 P55055 1/20 0.45
BAX Q07812 1/20 0.45
ALDH1A1 P00352 3/20 0.44
KDM4E B2RXH2 1/20 0.44
LMNA P02545 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MAPT P10636 1/20 0.44
CYP2A6 P11509 1/20 0.44
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL260494 0.90 PARP10 (0.55) ALDH5A1ABATKMT2APARP10PARP3
SCHEMBL346354 0.90 ALDH5A1 (0.73) ALDH5A1ABATESR1ESR2MEN1
4-Hydroxybenzaldehyde SCHEMBL28577371 0.90 ALDH5A1 (0.73) ALDH5A1ABATESR1ESR2MEN1
SCHEMBL7545244 0.90 ALDH5A1 (0.73) ALDH5A1ABATESR1ESR2MEN1
SCHEMBL7938161 0.84 ESR1 (0.74) ESR1ESR2MEN1KMT2APARP10
Phenol SCHEMBL17941265 0.81 LTA4H (0.59) ALDH5A1ABATESR1ESR2MEN1
SCHEMBL1663469 0.79 PARP10 (0.65) ALDH5A1ABATKMT2APARP10PARP3
SCHEMBL5050902 0.79 PARP10 (0.65) ALDH5A1ABATKMT2APARP10PARP3
Phenol SCHEMBL17941267 0.79 LTA4H (0.63) ALDH5A1ABATESR1ESR2MEN1
SCHEMBL22064844 0.78 ALDH5A1 (0.59) ALDH5A1ABATESR1ESR2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1363876-A1 GLUCOCORTICOID RECEPTOR MODULATORS Abbott Laboratories (US) 2003-11-26 EP disclosed
WO-2002064550-A1 GLUCOCORTICOID RECEPTOR MODULATORS ABBOTT LABORATORIES (US) 2002-08-22 WO disclosed