⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489361 | 0.77 | GRM4 (0.39) | — | |
| SCHEMBL1384870 | 0.76 | GRM4 (0.43) | — | |
| SCHEMBL2356296 | 0.72 | ALDH1A1 (0.33) | — | |
| SCHEMBL2354097 | 0.70 | KMT2A (0.34) | — | |
| SCHEMBL16324525 | 0.69 | HTT (0.35) | — | |
| SCHEMBL1427291 | 0.68 | ACHE (0.35) | — | |
| SCHEMBL29219229 | 0.68 | — | — | |
| SCHEMBL21877265 | 0.68 | MELK (0.40) | — | |
| SCHEMBL8782429 | 0.68 | MEN1 (0.38) | — | |
| SCHEMBL15555312 | 0.68 | GAA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10294262-B2 | 7-deazapurine nucleosides for therapeutic uses | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2019-05-21 | — | — | US | disclosed |
| US-20170240584-A1 | NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR,V.V.I. (CZ) | 2017-08-24 | — | — | US | disclosed |
| US-9624257-B2 | 7-deazapurine nucleosides for therapeutic uses | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ASCR, V.V.I. (CZ) | 2017-04-18 | — | — | US | disclosed |
| US-20160318970-A1 | NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ASCR, V.V.I. (CZ) | 2016-11-03 | — | — | US | disclosed |
| US-9321800-B2 | 7-deazapurine nucleosides for therapeutic uses | GILEAD SCIENCES, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-20150218201-A1 | NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2015-08-06 | — | — | US | disclosed |
| EP-2421879-A2 | NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES | Institute Of Organic Chemistry And Biochemistry As CR, V.V.I. (CZ) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121576-A2 | NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR,V.V.I. (CZ) | 2010-10-28 | — | — | WO | disclosed |
| US-20040157892-A1 | Pesticidal fluoroethyl pyrazoles | CROMPTON CO./CIE | 2004-08-12 | — | — | US | disclosed |