Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.74 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.69 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | EBP | Q15125 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695688 | 0.81 | OPRM1 (0.67) | OPRM1OPRL1OPRD1OPRK1DRD4 | |
| SCHEMBL3136902 | 0.81 | OPRL1 (0.86) | OPRM1OPRL1OPRD1OPRK1DRD4 | |
| Hydrochloric Acid SCHEMBL4813917 | 0.80 | OPRL1 (0.84) | OPRM1OPRL1OPRD1OPRK1DRD4 | |
| SCHEMBL18029400 | 0.79 | OPRL1 (0.70) | OPRM1OPRL1OPRD1OPRK1DRD4 | |
| SCHEMBL7104650 | 0.79 | OPRL1 (0.65) | OPRM1OPRL1OPRD1OPRK1DRD4 | |
| SCHEMBL9053345 | 0.78 | ABCB11 (0.85) | OPRM1OPRL1OPRD1ABCB11TP53 | |
| SCHEMBL6701358 | 0.78 | OPRM1 (0.76) | OPRM1OPRL1OPRD1OPRK1DRD4 | |
| SCHEMBL10079145 | 0.77 | OPRL1 (0.64) | OPRM1OPRL1OPRD1OPRK1DRD4 | |
| SCHEMBL12642624 | 0.77 | OPRL1 (0.67) | OPRM1OPRL1OPRD1OPRK1DRD4 | |
| SCHEMBL16363588 | 0.76 | OPRL1 (0.66) | OPRM1OPRL1OPRD1OPRK1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119354-A4 | PERIPHERALLY ACTING ANTI-PRURITIC OPIATES | ADOLOR CORP (US) | 2003-02-12 | — | — | EP | claimed |
| JP-2002527392-A | — | — | 2002-08-27 | — | — | JP | claimed |
| EP-1119354-A1 | PERIPHERALLY ACTING ANTI-PRURITIC OPIATES | Adolor Corporation (US) | 2001-08-01 | — | — | EP | claimed |
| WO-2000021530-A1 | PERIPHERALLY ACTING ANTI-PRURITIC OPIATES | ADOLOR CORPORATION (US) | 2000-04-20 | — | — | WO | claimed |