Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.74 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.73 |
| ▸ | MPO | P05164 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | HTR1A | P08908 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | NQO2 | P16083 | 1/20 | 0.73 |
| ▸ | HTR2B | P41595 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.73 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.73 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868871 | 0.94 | MTNR1A (0.65) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL28872503 | 0.89 | MTNR1A (0.83) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL14961084 | 0.89 | TRPM8 (0.63) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL25734745 | 0.88 | TRPV1 (0.66) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL30418479 | 0.88 | TRPV1 (0.66) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL7214730 | 0.87 | LTA4H (0.59) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL17213596 | 0.87 | MTNR1A (0.56) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL8869773 | 0.87 | LTA4H (0.59) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL26989647 | 0.86 | MTNR1A (0.55) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL6930033 | 0.86 | MTNR1A (0.81) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024008341-A1 | SEROTONIN ANALOGUES FOR USE IN TREATING METALLOPTOSIS-ASSOCIATED DISORDERS | INSTITUT CURIE (FR) | 2024-01-11 | — | — | WO | disclosed |
| EP-4101855-B1 | ANTITUMORAL COMPOUNDS | PHARMA MAR SA (ES) | 2023-08-02 | — | — | EP | disclosed |
| EP-4165023-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | Vertex Pharmaceuticals Incorporated (US) | 2023-04-19 | — | — | EP | disclosed |
| US-20230014907-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED | 2023-01-19 | — | — | US | disclosed |
| US-20230014907-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED | 2023-01-19 | — | — | US | disclosed |
| EP-3870234-B1 | ANTIBODY DRUG CONJUGATES COMPRISING ECTEINASCIDIN DERIVATIVES | PHARMA MAR SA (ES) | 2022-12-21 | — | — | EP | disclosed |
| EP-4101855-A1 | ANTITUMORAL COMPOUNDS | Pharma Mar S.A. (ES) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021252849-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-12-16 | — | — | WO | disclosed |
| WO-2021252849-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-12-16 | — | — | WO | disclosed |
| US-20170049904-A1 | POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF | BIOGEN MA INC. (US) | 2017-02-23 | — | — | US | disclosed |
| US-8927547-B2 | Pyrimidine derivatives | NOVIGA RESEARCH AB (SE) | 2015-01-06 | — | — | US | disclosed |
| US-8927547-B2 | Pyrimidine derivatives | NOVIGA RESEARCH AB (SE) | 2015-01-06 | — | — | US | disclosed |
| US-20140045845-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2014-02-13 | — | — | US | disclosed |
| US-8524660-B2 | Polyalkylene polymer compounds and uses thereof | BIOGEN IDEC MA INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20130089518-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2013-04-11 | — | — | US | disclosed |
| US-20130089518-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2013-04-11 | — | — | US | disclosed |
| US-20120014916-A1 | POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF | BIOGEN MA INC. | 2012-01-19 | — | — | US | disclosed |
| US-8017733-B2 | Covalent attachment of hydrophilic polymers, such as polyalkylene glycol polymers, also known as polyalkylene oxides, to biologically-active molecules | BIOGEN IDEC MA INC. (US) | 2011-09-13 | — | — | US | disclosed |
| WO-2004085395-A1 | MELATONIN DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL DYSFUNCTIONS | FAUST PHARMACEUTICALS (FR) | 2004-10-07 | — | — | WO | disclosed |
| US-6187805-B1 | TREATING CONDITION FOR WHICH SELECTIVE AGONISM OR ANTAGONISM OF 5-HT-6 RECEPTORS IS INDICATED BY ADMINISTERING COMPOUNDS SUCH AS N,N-DIMETHYL 2-(1-(BENZENESULPHONYL)-5-METHOXY-1H-INDOL-3-YL)ETHYLAMINE | MERCK SHARP & DOHME LTD. (GB) | 2001-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014907-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | APOL1, APOB, NPC1L1 | MTNR1A 3104/4885MTNR1B 2778/4885KMT2A 4362/4885 |
| US-20140045845-A1 | NOVEL PYRIMIDINE DERIVATIVES | TYMS, DPYD, TYMP | MTNR1A 3197/4885MTNR1B 2890/4885KMT2A 2440/4885 |
| US-20170049904-A1 | POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF | HAVCR2, TLR3, CCR8 | MTNR1A 3802/4885MTNR1B 3510/4885KMT2A 3367/4885 |
| US-20130089518-A1 | NOVEL PYRIMIDINE DERIVATIVES | DPYD, TYMS, TYMP | MTNR1A 3619/4885MTNR1B 3538/4885KMT2A 2089/4885 |
| US-20120014916-A1 | POLYALKYLENE POLYMER COMPOUNDS AND USES THEREOF | HAVCR2, TLR3, CCR8 | MTNR1A 3802/4885MTNR1B 3510/4885KMT2A 3367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.