Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8776835 | 0.85 | PTGS2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL5030910 | 0.79 | PTGS2 (0.40) | PTGS2PTGS1 | |
| SCHEMBL9119298 | 0.76 | PTGS2 (0.38) | PTGS2PTGS1 | |
| SCHEMBL7505970 | 0.75 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL9118988 | 0.75 | PTGS2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL9117197 | 0.75 | PLCG1 (0.37) | PTGS2 | |
| SCHEMBL3057707 | 0.73 | KEAP1 (0.40) | PTGS2 | |
| SCHEMBL5187074 | 0.72 | KEAP1 (0.34) | PTGS2 | |
| SCHEMBL5790751 | 0.72 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL27456829 | 0.72 | CA12 (0.40) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363669-A2 | METHOD OF USING A CYCLOOXYGENASE-2 INHIBITOR AND SEX STEROIDS AS A COMBINATION THERAPY FOR THE TREATMENT AND PREVENTION OF DISMENORRHEA | Pharmacia Corporation (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002062391-A2 | METHOD OF USING A CYCLOOXYGENASE-2 INHIBITOR AND SEX STEROIDS AS A COMBINATION THERAPY FOR THE TREATMENT AND PREVENTION OF DISMENORRHEA | PHARMACIA CORPORATION (US) | 2002-08-15 | — | — | WO | disclosed |