Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.66 |
| ▸ | MMP13 | P45452 | 5/20 | 0.66 |
| ▸ | MMP1 | P03956 | 5/20 | 0.66 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 3/20 | 0.45 |
| ▸ | MMP3 | P08254 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935166 | 0.91 | MMP1 (0.66) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL27512626 | 0.83 | MMP13 (0.75) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL1847769 | 0.80 | MMP1 (1.00) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL6927179 | 0.80 | MMP1 (1.00) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL6930723 | 0.80 | MMP13 (0.82) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL6928902 | 0.79 | MMP9 (0.69) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7324090 | 0.79 | MMP13 (0.71) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7952083 | 0.78 | MMP1 (0.65) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL6928539 | 0.78 | MMP13 (0.71) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL6929907 | 0.77 | MMP1 (0.77) | MMP9MMP13MMP1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970046-B1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH CORP (US) | 2003-12-10 | — | — | EP | claimed |