Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.65 |
| ▸ | MMP13 | P45452 | 8/20 | 0.65 |
| ▸ | MMP9 | P14780 | 7/20 | 0.65 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.65 |
| ▸ | MMP2 | P08253 | 7/20 | 0.43 |
| ▸ | MMP3 | P08254 | 5/20 | 0.43 |
| ▸ | MMP7 | P09237 | 3/20 | 0.40 |
| ▸ | MMP12 | P39900 | 3/20 | 0.40 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27512626 | 0.82 | MMP13 (0.75) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6927179 | 0.79 | MMP1 (1.00) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6930723 | 0.79 | MMP13 (0.82) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL1847769 | 0.79 | MMP1 (1.00) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6930804 | 0.78 | MMP9 (0.66) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6928902 | 0.78 | MMP9 (0.69) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL7324090 | 0.78 | MMP13 (0.71) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6929907 | 0.76 | MMP1 (0.77) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6932375 | 0.76 | MMP9 (0.73) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL6935166 | 0.76 | MMP1 (0.66) | MMP1MMP13MMP9ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331563-B1 | LOW MOLECULAR WEIGHT, NON-PEPTIDE INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME; TREATING ARTHRITIS, TUMOR METASTASIS, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, INSULIN RESISTANCE | WYETH HOLDINGS CORPORATION | 2001-12-18 | — | — | US | disclosed |