Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 8/20 | 0.41 |
| ▸ | DRD3 | P35462 | 6/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8390072 | 0.82 | SIGMAR1 (0.49) | SIGMAR1DRD2DRD3DRD4POLB | |
| SCHEMBL5239331 | 0.82 | SIGMAR1 (0.49) | SIGMAR1DRD2DRD3DRD4POLB | |
| SCHEMBL5239324 | 0.82 | SIGMAR1 (0.49) | SIGMAR1DRD2DRD3DRD4POLB | |
| Hydrochloric Acid SCHEMBL5760880 | 0.81 | SIGMAR1 (0.48) | SIGMAR1DRD2DRD3DRD4POLB | |
| SCHEMBL8491979 | 0.79 | HTR1D (0.44) | SIGMAR1DRD2DRD3DRD4HTR1D | |
| SCHEMBL8491004 | 0.79 | HTR1D (0.44) | SIGMAR1DRD2DRD3DRD4HTR1D | |
| SCHEMBL4100144 | 0.78 | DRD2 (0.61) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL4101018 | 0.78 | DRD2 (0.59) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL5243488 | 0.75 | MALT1 (0.47) | SIGMAR1DRD2DRD3DRD4HTR1D | |
| SCHEMBL5240125 | 0.75 | MTNR1A (0.41) | DRD2DRD3DRD4HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768307-B1 | Heterocyclic tertiary amines, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-26 | — | — | EP | disclosed |
| EP-0768307-A1 | Heterocyclic tertiary amines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1997-04-16 | — | — | EP | disclosed |