Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 10/20 | 0.41 |
| ▸ | DRD3 | P35462 | 8/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8491004 | 0.97 | HTR1D (0.44) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL8473729 | 0.80 | MTNR1A (0.40) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL6932136 | 0.79 | SIGMAR1 (0.42) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL4101018 | 0.76 | DRD2 (0.59) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL5239331 | 0.75 | SIGMAR1 (0.49) | DRD2DRD3DRD4SIGMAR1 | |
| SCHEMBL8390072 | 0.75 | SIGMAR1 (0.49) | DRD2DRD3DRD4SIGMAR1 | |
| SCHEMBL5239324 | 0.75 | SIGMAR1 (0.49) | DRD2DRD3DRD4SIGMAR1 | |
| SCHEMBL4100144 | 0.74 | DRD2 (0.61) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL8486031 | 0.74 | MTNR1A (0.53) | MTNR1A | |
| Hydrochloric Acid SCHEMBL10583535 | 0.74 | DRD2 (0.56) | HTR1DHTR1BDRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768307-B1 | Heterocyclic tertiary amines, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-26 | — | — | EP | disclosed |