Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.47 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.47 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932470 | 0.91 | ALDH1A1 (0.52) | BCL2L1POLBSLC9A1ALDH1A1LMNA | |
| SCHEMBL6935504 | 0.89 | MAPT (0.45) | BCL2L1POLBALDH1A1LMNA | |
| SCHEMBL6936874 | 0.88 | PDE7A (0.47) | BCL2L1PDE7APDE7BSLC9A1USP7 | |
| SCHEMBL6938143 | 0.87 | BCL2L1 (0.48) | BCL2L1POLBPDE7APDE7BPLA2G4A | |
| SCHEMBL27373702 | 0.86 | BCL2L1 (0.50) | BCL2L1POLBPDE7APDE7BPLA2G4A | |
| SCHEMBL6937291 | 0.86 | MEN1 (0.41) | BCL2L1POLBPDE7AALDH1A1LMNA | |
| SCHEMBL6936990 | 0.83 | SLC9A1 (0.42) | POLBPDE7ASLC9A1ALDH1A1LMNA | |
| SCHEMBL6937471 | 0.83 | SLC6A4 (0.47) | POLBPDE7ASLC9A1USP7ALDH1A1 | |
| SCHEMBL6934463 | 0.81 | SLC6A2 (0.45) | POLBSLC9A1ALDH1A1LMNA | |
| SCHEMBL6938838 | 0.79 | MAPT (0.40) | SLC9A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |