Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932140 | 0.91 | BCL2L1 (0.53) | ALDH1A1LMNAPOLBSLC9A1BCL2L1 | |
| SCHEMBL6935504 | 0.91 | MAPT (0.45) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL6937291 | 0.88 | MEN1 (0.41) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL6936990 | 0.88 | SLC9A1 (0.42) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL7074544 | 0.88 | ALDH1A1 (0.49) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL6934463 | 0.87 | SLC6A2 (0.45) | ALDH1A1LMNAPOLBMAPTSLC9A1 | |
| SCHEMBL27375128 | 0.86 | ALDH1A1 (0.54) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL6936874 | 0.84 | PDE7A (0.47) | LMNAMAPTSLC9A1BCL2L1 | |
| SCHEMBL6938838 | 0.81 | MAPT (0.40) | LMNAMAPTHTTSLC9A1 | |
| SCHEMBL6932986 | 0.81 | PDE7A (0.52) | LMNAPOLBMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |